If the microbiome of those who eat plant-based diets protects against the toxic effects of TMAO, what about changing the gut flora?
“About 2500 years ago, Hippocrates stated that “All diseases start from the gut” When we food With whole plant foods, our gut bacteria feed us beneficial compounds like butyrate, which our gut bugs make from fiber. On the other hand, if we feed them incorrectly, they can produce harmful compounds such as TMAO, which are produced in cheese, eggs, seafood and other meats.
We thought just TMAO contributed to cardiovascular diseases, such as heart disease and stroke, but, recently, it was connected to psoriatic arthritis, related with polycystic ovary syndrome and everything in between. I’m more worried about our leading killers, though. Of the ten leading causes of death in the United States, we know about its association with increased risk of heart disease and stroke, the number one and five killers, but more recently, the association found between blood levels of TMAO and the risk of various cancers are our number two killer. There may be a link between TMAO and cancer is attributed to inflammation caused by TMAO, but it can also be oxidative stress (free radicals), DNA damage or protein misfolding.
What about our fourth? leads killer, chronic obstructive pulmonary disease (COPD), such as emphysema? is TMAO related with premature death in patients with severe COPD, although this is unlikely to be due to their death from more cardiovascular disease.
Reference to stroke is casually – he did not expect anything. It is due to high blood pressure related with higher levels of TMAO, there is also a greater chance of clots to form in those with atrial fibrillation. Those with high levels of TMAO appear worse stroke and four times more likely to die.
Killer number six is Alzheimer’s disease. Can TMAO even enter our brains? Yes, TMAO is found in the cerebrospinal fluid that bathes the brain and levels of TMAO are higher in those with mild cognitive impairment and those with Alzheimer’s disease dementia. “In the brain, TMAO has been shown to cause neuronal senescence (meaning, deterioration with age), increase oxidative stress, disrupt mitochondrial function, and inhibit mTOR signaling, all of which contribute to brain aging and cognitive impairment.”
Killer number seven is diabetes and people with high levels of TMAO are about 50% chance of developing diabetes. Killer number eight is pneumonia and TMAO predicts fatal outcomes in patients with pneumonia even without overt heart disease. Kidney disease is killer number nine, and TMAO is hard related affects kidney function and predicts fatal consequences there as well. Over a five-year period, more than half of patients with chronic kidney disease who started with average or higher TMAO levels had died, while among patients in the lowest third of levels, nearly 90% survived.
How can we lower TMAO levels in our blood? Because TMAO originates from dietary sources, we can limit the consumption of foods rich in choline and carnitine. They are very widespread in food “, although we are talking about meat, eggs and milk. “Therefore, limiting foods rich in TMA-rich foods may not be practical.” We can only get vegetarian transplant? “Vegan donors provided investigators with fresh morning stool samples…”
If you remember, if you to give a vegan steak, despite all that carnitine, they get almost no TMAO compared to meat eaters, probably because veganism hasn’t increased the steak bugs in their guts. Check it out below and at 3:40 in my video Can vegan transplants lower TMAO levels?.
It’s amazing that even if you to give Plant-based eaters ate the equivalent of a 20-ounce steak every day for two months, only about half of them increased TMAO production, showing how much their gut flora had to change. The ability of plant feces to remove TMAO is almost non-existent. Instead of eating healthier, how about going vegan?
In a double-blind, randomized, controlled trial, research subjects or took vegetarian poo or their own poo was hosed down their nose and it didn’t work.
First of all, the vegetarians who were recruited for the study started taking TMAO on their own, in contrast to other studies where they did not prepare at all. This may be because the previous study required vegans to be vegan for at least a year, and this study did not. So, there wasn’t much change in TMAO after two weeks of taking the vegetarian bowl, but the vegetarian bowl that they took seemed to start with the ability to produce TMAO in the first place.
Thus, failure after vegan faecal transplantation “may be related to limited differences in the initial microbiome and continued omnivorous diet” after vegan-donor transplantation. If you’re only going to eat meat, what’s the point of trying to rebuild your microbiome? Well, the researchers didn’t want to switch people to a plant-based diet because they knew that alone could change our microbiome, and they didn’t want to introduce any additional factors. The bottom line is that there seems to be no shortcut. Maybe we just need to eat a healthy diet.
Dr.’s comment
Do you want to become a donor? Find out How to Become a Fecal Transplant Super Donor.
For more information on TMAO, check out the related posts below.
See microbiome topic page for even more.
