Common drugs, foods, and drinks can disrupt the integrity of our intestinal barrier and cause leaky gut.
Bowel movement, perforation of our intestine, may to be A new target for disease prevention and treatment. Our intestinal barrier, with all its tiny linings, covers an area of over 4,000 square meters, which is bigger than a tennis court, and requires about 40% of our body’s total energy expenditure to maintain.
There is growing evidence concerning “disruption of the integrity of the intestinal barrier” in the development of a number of conditions, including celiac disease and inflammatory bowel disease. The researchers measured intestinal permeability using blue food dye. It remained in the gut of healthy participants, but was detected in the blood of patients with severe sepsis with impaired intestinal barrier. However, you don’t need to stay in the ICU to develop a leaky gut. Just taking some aspirin or ibuprofen can do the trick.
Indeed, to take Two regular aspirin (325 mg pills) or two extra aspirin (500 mg pills) just once can increase our bowel movements. These results suggest that even healthy people should be cautious when using aspirin because it can cause gastrointestinal barrier dysfunction.
What about buffered aspirin, a combination of aspirin and antacid that theoretically “buffers” gastrointestinal irritation? It probably makes no difference: regular aspirin and bufferin both produced multiple erosions in the inner lining of the stomach and intestines. Researchers put a small amount on people’s throats and saw extensive erosion and redness in 90% of those who took aspirin or bufferin at the recommended dose. How many hours does it take? get to cause harm? None. It can happen within five minutes. acetaminophen, was sold like Tylenol in the United States, can cause gastrointestinal damage and may be a better choice if you don’t have problems with your liver. And instead of making things better, vitamin C supplements appeared which can make the increase in aspirin-induced toxicity even worse.
Interestingly, this may be the cause of NSAID drugs such as aspirin, ibuprofen and naproxen involved in up to 25% of food-induced anaphylaxis. In other words, they are more than 10 times more likely to have life-threatening food allergy attacks, possibly because these drugs increase the permeability of the stomach barrier and cause small food particles to enter the bloodstream. But can exercise also increase the risk?
Heavy training – for example, an hour at 70% of the maximum – can direct so much blood is diverted to our muscles and away from our internal organs that it can temporarily damage our intestines and cause light bowel movements. But it can be aggravated if athletes take ibuprofen or any other NSAID, which is unfortunately very common.
Alcohol can too to be risk factor for food allergy attacks for the same reason – increased intestinal secretions. But cut off alcohol, and our gut can heal.
What other dietary components can make the difference? Consuming too much saturated fat, found in meat, milk, and junk food, can lead to the growth of bad bacteria that produce rotten-egg sulfide gas that breaks down the protective mucus layer. You can see the process below and at 3:21 in my video Avoid these foods to prevent a leaky gut.
is said It should be clear that high-fat diets in general have negative effects on gut health by “disrupting the intestinal barrier system through a variety of mechanisms,” but most of the wide range of studies that have reported negative effects have been done in laboratory animals or in petri dishes. Are humans similarly affected? You won’t know for sure until you put it to the test.
Rates of obesity and other cardiometabolic disorders increased rapidly along with the transition from traditional low-fat diets to high-fat diets. We know that the disruption of our good gut flora is associated with a higher risk of many of these diseases, and studies using rodents show that a high-fat diet disrupts the microbiome when it disrupts the gut barrier that causes disease. However, to connect all the dots, we need an interventional human trial – and we got one: a six-month randomized controlled trial of the effects of dietary fat on the gut microbiota. It found that, indeed, high fat intake is associated with unfavorable changes in the gut microbiome and inflammatory factors in the blood. Note that it wasn’t even primarily saturated fat such as meat and milk. The researchers simply replaced refined carbohydrates with refined fats—swapping white rice and wheat flour for soybean oil. These findings suggest that countries that are westernizing their diets should be advised to increase their intake of dietary fat, while countries that have already adopted such diets should decrease.
Dr.’s comment
For more information on leaky gut, check out The small intestine theory of why animal products cause inflammation and How to cure dropsy with diet.
I also talked about leaky gut in my SIBO video: Friday Favorites: Tests, Fiber, and Low FODMAPs for Small Intestinal Bacterial Overgrowth (SIBO).
